Complications of testosterone deficiency in men include a wide variety of symptoms: loss of libido, erectile dysfunction, oligospermia or azoospermia, absence or regression of secondary sexual characteristics, progressive decrease in muscle mass, fatigue, depressed mood and an increased risk of osteoporosis.
Clomid for men works by blocking estrogen in the pituitary and hypothalamus. Thus, estrogen does not signal the brain to stop producing the Luteinizing hormone (LH). LH continues to be produced, as a result, testosterone production in the testes rises.
Testosterone secretion is the end result of a series of hormonal processes. Gonadoliberin (gonadotropin-releasing factor, GRF), which is secreted by the hypothalamus, controls the pulsed secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are secreted by the adenohypophysis. LH, in turn, regulates the production and secretion of testosterone by Leydig cells in the male testicles, while FSH helps in the induction of spermatogenesis.
Clomiphene increases testosterone levels and accordingly has a positive effect on the side effects of testosterone deficiency.
Testosterone is necessary for the development and maintenance of specific reproductive tissues (testicles, prostate, epididymis, seminal vesicle and penis) and secondary male sexual characteristics. It plays a key role in libido and erectile function and is necessary to initiate and maintain spermatogenesis.
Testosterone deficiency can be the result of the underlying disease or genetic disorders and is often an age-related complication.
Testosterone also has important functions that are not related to reproductive tissues. For example, it positively affects body composition by increasing nitrogen retention, which supports lean body mass, muscle size, and strength. It also acts on bones, stimulating bone formation.
Clomiphene increases testosterone levels, and accordingly has a positive effect on the side effects of testosterone deficiency, while the testes retain the ability to respond to gonadotropin stimulation.
In the United States, there are currently several forms of testosterone therapy: cream, gel, tablets, patch, or injections.
Recently, transdermal patches have become popular. But for example, the scrotal testosterone patch gives 5α-dihydrotestosterone (DHT) levels that are higher than physiological levels due to the high concentration of 5α-reductase in the scrotum skin. It is not known whether these elevated levels of DHT have any lasting health effects.
Non-scrotal systems are considered more convenient, and most patients achieve the right serum testosterone concentrations and still have normal levels of DHT.
Oral testosterone therapy is not recommended because the doses required for replacement therapy increase the risk of hepatotoxicity.
And although these types of testosterone replacement therapy are effective, each of them has side effects.
Compared to testosterone replacement therapy, Clomid for men with hypogonadism can be considered the best alternative because Clomiphene stimulates the body’s production of testosterone and is available in tablets and is convenient for taking.
Hormone replacement therapy is effective at first, but because Testicles do not need to produce endogenous testosterone with excess exogenous, this leads to partial or complete sterility with testicular atrophy.
Clomiphene is an antiestrogen related to tamoxifen, which blocks normal estrogen feedback at the hypothalamic level and subsequent negative feedback at the pituitary level. This leads to an increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In men, these increased levels of gonadotropins stimulate testicular Leydig cells and lead to the production of elevated levels of intrinsic testosterone.
Clomid does not directly affect the amount of estrogen. Its mechanism of action is to block estrogen access to the pituitary gland and increase follicle-stimulating and luteinizing hormones. This leads to increased secretion of testosterone by Leydig cells in the testes.
Important! In small doses (25-50 mg per day), the drug blocks estrogen receptors, but in large doses, it stimulates them. Therefore, in large doses, clomiphene does not exhibit the antiestrogenic, but estrogenic effect. In this regard, clomiphene is not used in large doses, even in combination with anabolic steroids.
Clomid is not a non-anabolic steroid. But, due to its properties, clomiphene is used as a mild alternative to steroids. Clomid is used by bodybuilders and athletes as a muscle restorative antiestrogen drug after a course of anabolic steroids (post-cycle therapy – PCT).
In mature men, testosterone levels decrease every 5 years by 10-15%. Testosterone is the main male androgen and performs an important function in men’s health. Therefore, when we talk about reduced testosterone, we are not only talking about reduced potency, but also about the greater risks of cardiovascular disease, diabetes, and osteoporosis.
Due to its ability to bind to estrogen receptors in the hypothalamus, Clomiphene Citrate significantly increases the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby leading to greater testosterone production in men with testicles. Due to these properties, Clomifen to some extent can be attributed to the group of anti-ageing drugs.
The main active ingredient, Clomiphene citrate, is sold under the trademarks Clomid and Serophene.
Clomiphene citrate – the colour of the drug can be white or pale yellow, almost odourless. One tablet of the drug contains 25/50/100 mg of the active substance, as well as some inactive ingredients: corn starch, lactose, magnesium stearate and sucrose.
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