The drug is a weak estrogen antagonist at the hypothalamus level, which stimulates the secretion of gonadoliberin, which acts on the pituitary gland, which releases luteinizing hormone (LH) and follicle-stimulating hormone (FSH). They stimulate testicles to synthesize more testosterone and more sperm.
Clomiphene increases the synthesis of LH and FSH in both young and older men. But in young men, the body responds better to therapy with Clomiphene, and they have revealed a significant increase in free and total testosterone than in older men.
Scientific studies have proven that with the following Clomiphene regimen, there are practically no side effects: 25 mg of clomiphene every other day; if necessary, the dosage is increased to 50 mg every other day (depending on the age of the man and testosterone values).
Clomiphene citrate is considered a well-tolerated drug and rarely causes significant side effects. During clinical trials, the most common adverse reactions included: nausea/vomiting (2%), chest discomfort (2%), visual symptoms (1%), headache (1%)
A final note on the side effects of Clomid: some may experience acne. Apparently, this is the most common effect when taking Clomid in PCT. In this case, not Clomid leads to this problem, but rather a high influx of testosterone produced. Most may not have this problem, but those with a genetic sensitivity to acne may find several acne on their back, shoulders, or chest.
Athletes who use Clomid on PCT can not be anxious since the tendency to side effects is almost a direct result of large dosages and long use. However, if a person has any signs of an allergic reaction to the drug: skin rash, itching or hives, swelling of the face, lips, or tongue, the blue tint of the skin, chest pain, shortness of breath, red swollen, painful area on the body, you should immediately contact to the doctor.
When using clomiphene on PCT, side effects develop in 1-10% of athletes. With an incorrectly increased dosage, the likelihood of these effects increases. When taking the drug for a long time in extremely high doses (more than 100 mg per day), you may experience:
Nervous system: dizziness, headache, drowsiness, slowing down the speed of mental and motor reactions, depression, increased irritability, insomnia.
Digestive system: nausea, vomiting, gastralgia, flatulence, diarrhea.
Allergic reactions: rash, allergic dermatitis.
Clomid for men can be a good alternative to testosterone therapy, but despite this, clomiphene should be taken after passing hormonal tests and under the supervision of a doctor.
Clomiphene therapy is usually well-tolerated, and side effects do not interfere with the continuation of treatment. But Clomid is not a bioidentical drug; its molecular structure does not mimic the human body’s natural compounds. Because of this, the risk of unwanted effects remains.
Common side effects include:
Changes in the digestive system include increased or decreased appetite, abdominal pain, nausea, and rarely vomiting.
Adverse effects on the central nervous system (CNS) occurring in <1% of patients. The central nervous system’s side effects include anxiety, nervousness, insomnia, lightheadedness and anxiety, and emotional lability. In rare cases, headaches, dizziness, mood swings are possible. Since clomiphene can affect psychomotor reactions, caution is required for people driving vehicles or performing responsible work.
Clomid acts on the pituitary gland, so it can increase in size and compress the optic nerve, which leads to temporary visual impairment: blurry images, circles in front of the eyes, photophobia, and ripples on the periphery of the review. These side effects are quite rare, in about 1% of patients, but they cannot be ignored. Such side effects are reversible, but the drug should be stopped. In most cases, visual changes are reversible within a few days after stopping the drug. For this reason, Clomid is not recommended for persons who spend a lot of time behind the wheel when constant visual activity is required. Or it is recommended that you do not drive behind the wheel for a while.
Side effects of Clomid also include possible visual impairment. Data show that approximately 1-2% of the total number of people who take Clomid may experience blurred vision. If this happens, you must immediately stop taking the drug and be considered an alternative to Clomid. In most cases, after stopping the drug, vision returns to normal. However, several visual impairment cases have not been corrected by stopping the drug over the years. As a rule, such cases were associated with long-term use of the drug in extremely high doses.
Conclusions: Clomid is considered well-tolerated anti-estrogen and does not lead to serious side effects in either men or women. However, some side effects are possible. For athletes, to protect against estrogenic side effects, it is recommended to take Clomid 50 mg per day or every other day. To test the effectiveness of clomiphene citrate, you can take a blood test and ensure that testosterone levels are restored.